This paper analyzes the factors that drive transformation IAIN Antasari into UIN Pangeran Antasari. These changes are caused by transforming the madrasa curriculum, demand on work market that require a variety of skills as a result of modernization, social and cultural changes in globalization as impact from modern communication and transportation technologies and moral decacency in society. Transfor- mation to UIN should consederate the integration of science and higher education access for all. UIN should answer society demand of religios passion and universal human problem.